Michelle Huth

Wt1 splice isoforms bias lineage programmes during formative pluripotency

The paper identifies Wt1 splice isoforms as regulators of lineage-associated transcriptional programs during formative pluripotency, showing that alternative splicing tunes lineage bias.

FoxO transcription factors actuate the formative pluripotency specific gene expression programme

This study identifies FoxO transcription factors as essential for transitioning from naive to formative pluripotency by regulating enhancer activity through AKT signaling.

Cooperative molecular networks drive a mammalian cell state transition

The paper identifies molecular networks driving the transition from naive to formative pluripotency in mammalian cells using genetic and transcriptomic analyses.