Nicolas C. Rivron

The paper shows that human embryo implantation involves Syncytin-2/MFSD2A-mediated cell fusion between blastoids and endometrial epithelial cells, preventing implantation when MFSD2A is knocked out.

This study develops a feeder-free serum-coated system for culturing naive human pluripotent stem cells, maintaining their developmental potential and reducing contamination and mutations.

This paper introduces a high-throughput single-cell proteomics workflow achieving 5300 protein groups per cell with high accuracy, enabling the study of cellular heterogeneity and lineage differentiation.

This study identifies FoxO transcription factors as essential for transitioning from naive to formative pluripotency by regulating enhancer activity through AKT signaling.

This study shows that human blastoids and pluripotent stem cells can enter a dormant state via mTOR inhibition, with distinct temporal dynamics compared to mice.

The paper shows that embryonic signals convert trophoblast stem cells into polar-like cells that pattern the blastocyst axis in vitro.

This paper introduces scPECLR, a probabilistic algorithm that reconstructs cellular lineage trees at single-cell division resolution using 5-hydroxymethylcytosine sequencing in mouse embryos.

The paper maps gene expression changes during meiotic prophase-I in mice spermatogenesis, identifying key transitions and gene regulation patterns.

The paper shows that chemically-defined conditions and signaling molecules can generate primitive endoderm-like cells and support post-implantation-like epiblast development in vitro.