KmerSignificance Score: A discriminative and biologically-informed framework for viral k-mer prioritization
Dylan Lebatteux, Florian Corso, Hugo Soudeyns…·Abdoulaye Baniré Diallo
KmerSignificance Score (KSS) prioritizes viral k-mers by integrating strain-distinguishing capacity, mutation impact, and functional importance, achieving superior classification performance and cross-dataset comparability.