Thomas M. Carlile

Spatial transcriptomics reveals heterogeneous cell-cell interactions among brain regions in a cuprizone model consistent with multiple sclerosis lesions

The paper uses spatial transcriptomics to analyze cell-cell interactions in a cuprizone model, finding region-specific changes and partial translatability to multiple sclerosis lesions.

High-Resolution Characterization of rAAV Genomes for Vector Quality Using Long-Read Sequencing

This paper uses long-read sequencing to characterize rAAV genomes and impurities, enabling better quality control in gene therapy production.

Scaling up spatial transcriptomics for large-sized tissues: uncovering cellular-level tissue architecture beyond conventional platforms with iSCALE

iSCALE predicts super-resolution gene expression and annotates tissue architecture in large tissues, revealing features missed by conventional spatial transcriptomics.

Comparative snRNAseq study of C9orf72, SOD1, and sALS spinal cord

This study compares snRNAseq data from C9orf72, SOD1, and sporadic ALS spinal cords, identifying shared and distinct molecular features across cell types.

Conserved Methyltransferase Spb1 Targets mRNAs for Regulated Modification with 2′-O-Methyl Ribose

The paper identifies 2′-O-methyl ribose (Nm) as a prevalent mRNA modification in yeast, showing that Spb1 methylates ribosomal protein mRNAs and that its expression is required for normal levels of target mRNAs.