Kaiwen He

This study identifies a postsynaptic TAK1-GluN2B signaling axis that maintains synaptic integrity and cognitive function, with reduced TAK1 levels contributing to age-related hippocampal decline.

The paper shows that cortico-striatal activity decoupling occurs early in a Parkinson's Disease-like mouse model and is cell-type and behavior-specific.

The paper shows that LTP and E/I ratio oscillate with the light-dark cycle in mouse CA1, reversing direction after puberty.

This study identifies LC hyperactivity driven by α2A-AR and Kv channel dysfunction as a cause of early sleep disruption in 5xFAD mice.

This study identifies dAux's role in regulating lysosomal V-ATPase assembly through phosphorylation, which is critical for α-synuclein degradation in glia and PD progression.

The paper shows that cortical parvalbumin-positive neurons exhibit daily modulation in inhibitory synaptic transmission, regulated by sleep and acetylcholine.