Margaret Su-chun Ho

VAMP7-dependent mitochondria-lysosome contacts regulate glial mitochondrial dynamics and dopaminergic neuron survival

This study shows that VAMP7 regulates mitochondrial-lysosome contacts in fly glia, affecting mitochondrial dynamics and dopaminergic neuron survival through Rab7 GTP hydrolysis.

A Pvr-AP-1-Mmp1 signaling pathway is activated in astrocytes upon traumatic brain injury

The paper identifies a Pvr-AP-1-Mmp1 signaling pathway activated in astrocytes after traumatic brain injury and shows endocytosis regulates its activity.

dAux orchestrates the phosphorylation-dependent assembly of the lysosomal V-ATPase in glia and contributes to α-synuclein degradation

This study identifies dAux's role in regulating lysosomal V-ATPase assembly through phosphorylation, which is critical for α-synuclein degradation in glia and PD progression.

Cyclin-G-associated kinase GAK/dAux regulates autophagy initiation via ULK1/Atg1 in glia

This study identifies GAK/dAux as a regulator of glial autophagy, showing it interacts with ULK1/Atg1 and modulates autophagosome formation and flux.

A LRRK2/dLRRK-mediated lysosomal pathway that contributes to glial cell death and DA neuron survival

This study identifies a LRRK2/dLRRK-mediated lysosomal pathway in glia that contributes to glial cell death and dopaminergic neuron survival in Parkinson's disease.