Alfredo Kirkwood

This study shows that adult mice can exhibit reversible presynaptic plasticity at thalamocortical synapses through visual deprivation and light reintroduction.

This study links cognitive resilience in aging degus to preserved GABAergic function in the hippocampal CA3 region, identified through behavioral and electrophysiological assessments.

The paper shows that LTP and E/I ratio oscillate with the light-dark cycle in mouse CA1, reversing direction after puberty.

The paper examines daily oscillations of the excitation/inhibition ratio in two mouse models of autism and finds disruptions in oscillation patterns rather than overall ratio levels.

This study shows that prolonged visual deprivation in adult mice induces reversible, non-homeostatic plasticity at thalamocortical synapses in layer 4 pyramidal neurons.

This paper generates two knock-in mouse models with human SYNGAP1 mutations causing intellectual disability, showing reduced protein levels and recapitulating key disease features.

This study shows SynGAP regulates synaptic plasticity and cognition through phase separation, not its catalytic activity.

The paper shows that membrane capacitance in mouse excitatory neurons changes significantly over a daily light cycle, but not in inhibitory interneurons.

This study shows that GluN2B-containing NMDA receptors are essential for both initial LTD and subsequent homeostatic increases in visual cortex plasticity following monocular deprivation.

The paper shows that monocular deprivation in mouse visual cortex causes an all-or-none elimination of pyramidal cell connections to parvalbumin-positive interneurons, which is necessary for ocular dominance plasticity.

The paper examines afterhyperpolarization amplitude in aged Long-Evans rats, finding a reduction in cognitively impaired individuals compared to Fisher 344 rats.

This paper demonstrates that neuromodulators can induce bidirectional shifts in visual cortical responses through a pull-push mechanism in vivo.

The paper shows that inhibitory synapses in PV-INs recover resources dynamically, enabling linear rate encoding and controlling cortical visual response gain.

This study shows that aging-related cognitive decline in rats is linked to reduced inhibition in the dentate gyrus in response to lateral entorhinal input.

The paper shows ionic current correlations exist in mouse neurons, extending findings from invertebrates to vertebrates.