Robust CRISPR Screens Identify TPL1 as a Novel Long Noncoding RNA Driving Triple-Negative Breast Cancer Hallmarks
Ramesh Elango, Sunandini Ramnarayanan, Radhakrishnan Vishnubalaji, Lütfiye Yıldız Özer, Michela Coan, Yifan Yu, Sunkyu Choi, Tina Uroda, Carlos Pulido-Quetglas, Frank Schmidt, Khalid Ouararhni, Ayman Al Haj Zen, Rory Johnson, Nehad M. Alajez
The paper identifies TPL1 as a novel long noncoding RNA that drives triple-negative breast cancer hallmarks through multiple molecular mechanisms.
bioRxiv · Aug 6, 2025 · PreprintCancer Biology