The CCL17-CCR4 axis is critical for mutant STAT6-mediated microenvironmental remodelling and therapeutic resistance in Relapsed/Refractory Diffuse Large B Cell Lymphoma
Madelyn Jean Abraham, Cynthia Guilbert, Natascha Gagnon, Christophe Gonçalves, Alexandre Benoit, Kelly Tran, Owen Hiltebrand, Ryan N. Rys, Samuel E.J. Preston, Ryan D. Morin, Wilson H. Miller, Nathalie A. Johnson, Sonia Victoria Del Rincon, Koren Kathleen Mann
This study identifies the CCL17-CCR4 axis as a driver of therapeutic resistance in STAT6D419 mutant rrDLBCL by promoting T cell infiltration and microenvironmental changes.
Cancer Immunology Research · Dec 29, 2025Peer-reviewedCancer Biology