The CCL17-CCR4 axis is critical for mutant STAT6-mediated microenvironmental remodelling and therapeutic resistance in Relapsed/Refractory Diffuse Large B Cell Lymphoma
Madelyn Jean Abraham, Cynthia Guilbert, Natascha Gagnon…·Koren Kathleen Mann
This study identifies the CCL17-CCR4 axis as a driver of therapeutic resistance in STAT6D419 mutant rrDLBCL by promoting T cell infiltration and microenvironmental changes.