This study identifies RAB1A as a vulnerability in uveal melanoma through dual inhibition of MNK1/2 and mTOR, showing it disrupts protein trafficking and blocks liver metastasis.

Cell Death and Differentiation · Feb 18, 2026Peer-reviewedCancer Biology

The CCL17-CCR4 axis is critical for mutant STAT6-mediated microenvironmental remodelling and therapeutic resistance in Relapsed/Refractory Diffuse Large B Cell Lymphoma

Madelyn Jean Abraham, Cynthia Guilbert, Natascha Gagnon, Christophe Gonçalves, Alexandre Benoit, Kelly Tran, Owen Hiltebrand, Ryan N. Rys, Samuel E.J. Preston, Ryan D. Morin, Wilson H. Miller, Nathalie A. Johnson, Sonia Victoria Del Rincon, Koren Kathleen Mann

This study identifies the CCL17-CCR4 axis as a driver of therapeutic resistance in STAT6D419 mutant rrDLBCL by promoting T cell infiltration and microenvironmental changes.

Cancer Immunology Research · Dec 29, 2025Peer-reviewedCancer Biology

Mouse nephron formation is impaired by moderate-dose arsenical exposure

Carlos Agustín Isidro Alonso, Jenna Haverfield, Gabriela Regalado, Sihem Sellami, Natascha Gagnon, Ajay Rajaram, Pierre Fiset, Tomoko Takano, Aimee K. Ryan, Koren Kathleen Mann, Indra Rani Gupta

This study shows that moderate-dose arsenical exposure during mouse kidney development impairs nephron formation and increases the risk of chronic kidney disease.

Toxicology and Applied Pharmacology · Apr 29, 2025Peer-reviewedDevelopmental Biology