Author
Centre for Human GeneticsORCID 0000-0002-1200-9825Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Joshua A. Bull, Joshua W. Moore, Shania M. Corry…·Helen Mary Byrne
MuSpAn, a Python library of over 100 spatial methods, quantifies multiscale tissue organisation and maps cancer-associated fibroblast subtypes to distinct immune niches in mouse colorectal tumours.
Corinne Molyneux, Rhianna O’Sullivan, Eoghan J. Mulholland-Illingworth…·Christopher J. Tape
This study identifies stromal prostaglandin E2 as a key regulator of cell-fate plasticity in colorectal cancer, showing it converts chemosensitive stem cells into chemorefractory, prometastatic cells.
Eoghan J. Mulholland, Hayley L. Belnoue-Davis, Gabriel N. Valbuena…·Simon John Leedham
Pathological epithelial GREM1 expression induces therapeutically reversible ectopic stem cell niches through stromal remodelling.
Joshua A. Bull, Eoghan J. Mulholland, Joshua W. Moore…·Simon John Leedham
The paper develops spatial descriptors using mathematical tools to analyze cell interactions in colorectal cancer progression and demonstrates their utility in identifying disease-related pathways.