Rhianna O’Sullivan

This study identifies that epithelial stem cell fate, not DNA damage, determines chemoradiotherapy response in rectal cancer by analyzing patient-derived organoids and using SPARTA to validate findings.

This study identifies stromal prostaglandin E2 as a key regulator of cell-fate plasticity in colorectal cancer, showing it converts chemosensitive stem cells into chemorefractory, prometastatic cells.

This study shows that inhibiting Ephrin signaling disrupts stromal-cancer interactions and reduces metastasis in pancreatic cancer using mouse models.

SIGNAL-seq measures RNA and PTMs in single cells to analyze inter- and intra-cellular signaling in the tumor microenvironment.