Cancer BiologybioRxivPreprint
Stromal Prostaglandin is a Dominant Spatial Regulator of Cell-fate Plasticity in Colorectal Cancer
Corinne Molyneux, Rhianna O’Sullivan, Eoghan J. Mulholland-Illingworth…·Christopher J. Tape
This study identifies stromal prostaglandin E2 as a key regulator of cell-fate plasticity in colorectal cancer, showing it converts chemosensitive stem cells into chemorefractory, prometastatic cells.