The paper shows estrogen reduces DMRT1 protein levels in female chicken gonads during ovarian development, suggesting estrogen signaling regulates primary sex determination.

3 citations

experimental assay

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Developmental BiologyProceedings of the National Academy of SciencesPeer-reviewedMar 3, 2021

Primary sex determination in chickens depends on DMRT1 dosage, but gonadal sex does not determine secondary sexual characteristics in adult birds

Jason Ioannidis, Güneş Taylor, Debiao Zhao…·Michael Clinton

180 citationstop 1%

experimental assay

𝕏 PostBluesky

Developmental BiologyDevelopmentPeer-reviewedJan 1, 2020

In the chick embryo, estrogen can induce chromosomally male ZZ left gonad epithelial cells to form an ovarian cortex which supports oogenesis

Silvana Guioli, Debiao Zhao, Sunil Nandi…·Robin Howard Lovell-Badge

The paper shows estrogen can induce ZZ male gonad cells to form an ovarian cortex in chick embryos, supporting oogenesis, but a male medulla may hinder germ cell maturation.

46 citationstop 3%

experimental assay

𝕏 PostBluesky