Robin Howard Lovell-Badge

This study identifies BDNF as a key signal for pituitary stem cell differentiation and homeostasis in mouse models of glucocorticoid deficiency.

The paper identifies key transcription factors and regulatory elements involved in mouse gonadal sex determination through integrated transcriptomic and chromatin accessibility analyses.

This study identifies a global temporal chromatin programme in vertebrate neural progenitors that integrates with spatial patterning to regulate cell fate and identity.

This paper shows SOX2 induces fetal reprogramming and reversible dormancy in colorectal cancer, promoting tumour progression and drug tolerance.

The paper shows that most gonadotrophs in adults originate from postnatal pituitary stem cells during minipuberty, while embryonic gonadotrophs are maintained, revealing a dual origin.

The paper investigates FOXL2's role in ovarian development through multi-omics analysis, identifying its binding partners and regulatory targets, and shows that USP7 deletion causes infertility.

The paper uses single-cell technologies to study pituitary stem cell heterogeneity and shows that differentiation is more frequent and diverse than previously thought, with maintenance of progeny dependent on the microenvironment.

This study shows that Sox3 absence causes hypopituitarism by affecting median eminence NG2-glia, which can be rescued by aspirin or gut microbiota changes.

This paper describes in-vitro protocols to differentiate mouse and human pluripotent cells into gonadal progenitors, revealing their functional equivalence to in-vivo cells and modeling DSDs.

This study shows p27 represses SOX2 and its downstream targets to regulate cell cycle exit in adult neurogenesis and oligodendrogenesis.

The paper identifies a distinct transcriptional programme in pregranulosa cells before primordial follicle activation using single-cell RNA sequencing in mice.

This study identifies TRIM28's role in preventing female-to-male sex reversal in the adult mouse ovary by maintaining the ovarian pathway through SUMOylation.

The paper shows that SOX9 is essential for dentate gyrus development by regulating astrocytic scaffold formation in the cortical hem.

The paper shows estrogen can induce ZZ male gonad cells to form an ovarian cortex in chick embryos, supporting oogenesis, but a male medulla may hinder germ cell maturation.

The paper challenges the established model of neural induction by showing that cells commit to anterior or posterior regional identities before acquiring neural identity.