An‐Ping Zeng

This study uses AAV-delivered LplA to rescue lethal mitochondrial lipoylation defects in Lipt1-deficient mice, improving survival, motor function, and cardiac health.

This paper introduces Pinal, a foundation model that designs proteins from natural language descriptions, achieving functional alignment and experimental success in four design tasks.

This study introduces bacterial lipoate protein ligases to restore lipoylation and respiration in human and mouse models with lipoylation pathway deficiencies.

The paper introduces SaprotHub, a platform that simplifies training and sharing of protein language models, enabling non-experts to build and collaborate on customized models.

This paper introduces dSort-Seq, a deep-learning-assisted Sort-Seq method for high-throughput profiling of gene expression characteristics with high precision, and demonstrates its application in studying noise and dose-response relationships in E. coli.