Acid sphingomyelinase deactivation post-ischemia/ reperfusion promotes cerebral angiogenesis and brain remodeling via small extracellular vesicles
Ayan Mohamud Yusuf, Nina Hagemann, Xuejing Zhang, M Zafar, Tanja Hussner, Carolin Bromkamp, Carlotta Martiny, Tobias Tertel, Verena Börger, Fabian Schumacher, Fiorella Andrea Solari, Mike Hasenberg, Christoph Kleinschnitz, Thorsten Roland Doeppner, Burkhard Kleuser, , Dirk Matthias Hermann
The paper shows that antidepressants inhibit acid sphingomyelinase, reducing brain damage after ischemia/reperfusion and promoting angiogenesis via exosome release.
bioRxiv · Mar 1, 2021 · PreprintNeuroscience