Christoph Kleinschnitz

This study examines age-related changes in peripheral nerves and Schwann cells in a mouse model of late-onset spinal muscular atrophy, revealing myelin abnormalities and altered Schwann cell states.

This study shows that heartbeat sound activates PIEZO channels in astrocytes, promoting extracellular matrix synthesis and neural differentiation in human brain organoids.

This study shows that post-stroke T3 treatment reduces infarct volumes and stabilizes the blood-brain barrier in mice, with optimal timing and dosage identified.

The paper shows that antidepressants inhibit acid sphingomyelinase, reducing brain damage after ischemia/reperfusion and promoting angiogenesis via exosome release.

This study shows that extracellular matrix stabilizes inhibitory synapses to maintain excitation-inhibition balance in neuronal networks.

This study identifies NOX5 as a key mediator of calcium-dependent reactive oxygen species formation and blood-brain barrier breakdown after reperfusion in stroke, suggesting NOX inhibition as a potential therapeutic strategy.