Dirk Matthias Hermann

This study shows that hyperlipidemia reduces the neuroprotective effects of MSC-derived extracellular vesicles, but DNase-I treatment restores their efficacy by rebalancing immune responses.

This study shows that monocytes are essential for the neuroprotective effects of MSC-EVs in stroke, as their depletion negates these benefits and leads to immune system dysregulation.

This study shows that neutralizing extracellular histones reduces secondary brain injury and improves recovery after ischemic stroke complicated by pneumonia.

This study shows that heartbeat sound activates PIEZO channels in astrocytes, promoting extracellular matrix synthesis and neural differentiation in human brain organoids.

This study identifies NR4A1 as a neutrophil-intrinsic regulator that reduces stroke severity by limiting inflammation and brain damage through pharmacological modulation.

This study shows that structural changes in perineuronal nets and their GABAergic synapses occur before motor coordination recovery after stroke in mice.

VesselExpress automates 3D blood vasculature analysis in LSFM data, enabling rapid and unbiased quantification of vascular parameters across multiple organs.

The paper shows that antidepressants inhibit acid sphingomyelinase, reducing brain damage after ischemia/reperfusion and promoting angiogenesis via exosome release.

This study shows that experimental stroke in mice increases ACE2 expression and inflammation in the lungs, potentially explaining why stroke patients are at higher risk for severe SARS-CoV-2 infections.

This study shows that extracellular matrix stabilizes inhibitory synapses to maintain excitation-inhibition balance in neuronal networks.

This study shows that post-acute administration of S44819 at 10 mg/kg improves skilled forelimb movement recovery in rats after stroke, with effects lasting after drug washout.