Burkhard Kleuser

A Novel Rapid Host Cell Entry Pathway Determines Intracellular Fate of Staphylococcus aureus

This study identifies a rapid host cell entry pathway for Staphylococcus aureus that influences intracellular fate, leading to different replication rates and host cell death compared to slower pathways.

Chlamydia trachomatis deploys sphingolipids for genome organisation

This study identifies sphingolipids, specifically sphingomyelin, as key molecules involved in DNA condensation and developmental regulation in Chlamydia trachomatis.

Kidney disease reprograms microbiome-host signaling to promote heart failure

This study identifies a microbiome-AhR-IL-17A axis that drives CKD-associated cardiac fibrosis and shows that AhR inhibition prevents remodeling.

Monitoring Sphingomyelin Biosynthesis at Nanoscale Resolution by Expansion Microscopy

This paper develops a fluorometric assay combined with expansion microscopy to visualize sphingomyelin biosynthesis at nanoscale resolution in cells.

A genome-wide genetic screen identified targets for destabilizing the parasitophorous vacuole of Chlamydia trachomatis

The paper identifies CpoS as a key effector for maintaining Chlamydia trachomatis vacuole integrity by regulating sphingolipid supply and shows that disrupting this pathway can clear infection without harming host cells.

Fertilization by short-term stored sperm alters DNA methylation patterns in common carp (Cyprinus carpio) embryos at single-base resolution

The paper examines how short-term sperm storage affects DNA methylation in common carp embryos at single-base resolution, identifying 3313 genes with altered methylation.

Acid sphingomyelinase deactivation post-ischemia/ reperfusion promotes cerebral angiogenesis and brain remodeling via small extracellular vesicles

The paper shows that antidepressants inhibit acid sphingomyelinase, reducing brain damage after ischemia/reperfusion and promoting angiogenesis via exosome release.