Daniela Zanetti

The paper investigates causal relationships between gut microbiome traits and age-related phenotypes, finding significant associations with ApoM protein levels and other plasma proteins.

This study identifies plasma proteins associated with insulin sensitivity across diverse populations and shows their response to interventions, with some proteins suggesting causal relationships and therapeutic targets.

The paper identifies CXCL12 as a genetic driver of coronary artery anatomy variation through GWAS and mouse models, showing its role in fetal coronary development.

This study uses Mendelian randomization to show that increased alcohol consumption is associated with higher cardiometabolic risks, including elevated blood pressure and mortality, but lower triglycerides and HbA1C.

This study identifies 592 genetic loci associated with 184 plasma proteins in 26,494 individuals and finds causal relationships between protein levels and disease.

The paper conducts genome-wide association studies on urinary biomarkers in the UK Biobank, identifying 78 novel loci and confirming existing associations, linking these biomarkers to chronic diseases.

This study uses Mendelian randomization to show lower birthweight causally increases risk of CAD and T2D in adulthood, independent of adult BMI and hypertension.

This study shows that differences in GWAS signals across populations can be explained by factors like MAF and LD without needing true causal effect size differences.