Xiaochen Fan

A stem cell-derived human vein-to-artery endothelial conversion model mirrors angiogenesis-derived embryonic arteries; VEGF plus PI3K inhibition alone yields 92% DLL4+CXCR4+ endothelium by 48 hours.

The paper uses Perturb-seq in mice to identify genes that promote collateral artery formation by comparing gene expression between guinea pigs and mice.

The paper benchmarks large language models for cell-type and gene set annotation using AnnDictionary, finding high accuracy in cell-type annotation and strong functional gene set recovery.

The paper identifies CXCL12 as a genetic driver of coronary artery anatomy variation through GWAS and mouse models, showing its role in fetal coronary development.

This study shows that overexpressing Dach1 in endothelial cells extends coronary arteries and improves heart function after myocardial infarction in mice.

The paper identifies a TWIST1-chromatin regulatory module critical for neural crest cell differentiation and craniofacial patterning through protein interaction and perturbation studies.

This study identifies TWIST1 homodimers and heterodimers with E-proteins as key regulators of lineage-specific differentiation, revealing their distinct roles in mesoderm, neural crest, and endoderm development.