Lasse Folkersen

The paper validates nine polygenic risk scores in family and multi-ancestry datasets, showing their potential to reduce disease risk through embryo selection in IVF.

The paper presents an optimized variant calling pipeline that reduces storage and runtime costs for DNA sequencing analysis.

The paper identifies pQTLs for 91 plasma proteins, finds novel associations, and uses MR to uncover causal roles in immune-mediated diseases, suggesting new therapeutic targets.

This study explores consumer motivations, emotional reactions, and actions taken after receiving polygenic risk scores from a third-party website.

This paper introduces a method to convert polygenic scores to an absolute scale using summary statistics, validated on UK Biobank data, and provides web tools for implementation.

This study identifies 592 genetic loci associated with 184 plasma proteins in 26,494 individuals and finds causal relationships between protein levels and disease.

This study evaluates polygenic scoring methods in a reference-standardized framework, finding that LDPred2, lassosum, and PRScs provide the best predictive performance.

This study evaluates gene expression risk scores (GeRS) for predicting neuropsychiatric and anthropometric traits, finding they improve prediction when combined with polygenic risk scores (PRS).

This study identifies 13 genome-wide significant loci associated with SARS-CoV-2 infection or severe COVID-19 through a global meta-analysis of 49,562 patients.

Impute.me provides an open-source tool for calculating and interpreting polygenic risk scores from consumer genetic data to better communicate genetic risk for complex diseases.

The paper identifies pQTLs for cardiovascular proteins and uses them to evaluate drug targets and suggest new candidates for precision medicine.

The paper identifies a genetic subgroup within depression linked to age of natural menopause using UK Biobank data, but finds no replication in other cohorts.

This study connects cardiovascular risk variants to disease-related pathways using high-resolution genomic interaction maps in relevant cell types.

The paper shows that HLA-DRB1 shared epitope alleles' risk for ACPA-positive RA is significantly influenced by interactions with non-HLA SNPs.

This study identifies two new genetic loci associated with aortic valve stenosis through a large genome-wide association study.