Charleston Noble

This paper introduces daisy-chain gene drives that can alter local populations without global spread, enabling ethical use and community control.

This study shows that CRISPR gene drives can invade wild populations even with resistance alleles, challenging claims that they are safe for release.

This study mathematically analyzes the evolutionary dynamics of CRISPR gene drives and shows that resistance alleles challenge their effectiveness, but an alternative design improves stability.

The paper introduces a daisy quorum drive system designed to alter wild populations within defined boundaries and restore engineered genes to their original state.

This paper describes a gene drive system using repeated genomic elements as a generational clock to limit the spread of engineered traits.