Joshua A. Englert

The paper measures miR-146a levels in different fluid samples from ventilated patients and finds that lower levels in alveolar space correlate with mortality, while plasma levels do not.

This study identifies Annexin A2 as a regulator of surfactant function during injurious ventilation, showing its role in maintaining surfactant composition and preventing lung stiffness in ARDS.

The paper develops a cell-based platform to generate Resolvin-loaded extracellular vesicles that reduce pulmonary inflammation in mice.

The paper uses scRNA-seq to identify unique macrophage and monocyte populations in a murine model of ozone-induced asthma exacerbation, linking them to inflammatory pathways and bronchial constriction.

This study introduces a ventilator-on-a-chip model to simulate and analyze the effects of different mechanical forces on lung barrier integrity during mechanical ventilation.

This study shows that overexpressing miR-146a via nanoparticles reduces lung injury during mechanical ventilation by targeting mechanotransduction in macrophages.

This study shows that mTORC1 activation during mechanical ventilation worsens lung injury in ARDS and that inhibiting mTORC1 can prevent ventilator-induced lung injury.