Author

Melissa G Carrizales

Yale UniversityORCID 0000-0002-1257-5472Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Anthony J. KoleskeiD· 2 shared Amanda T. Jeng· 1 shared AndrewJ.M. Boulton· 1 shared Charles A. GreeriD· 1 shared Cindy Manriquez-Rodriguez· 1 shared Ellen E CorcoraniD· 1 shared Khanh K Nguyen· 1 shared Matthew J Vitarelli· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

Anthony J. KoleskeORCID

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2 papers

Recent·Most cited

BiochemistryJournal of Biological ChemistryPeer-reviewedJun 26, 2025

Genetic variants linked to neurodevelopmental disorders within the β3-β4 loop of the TRIO PH2 domain release autoinhibition of GEF2 activity.

Melissa G Carrizales, AndrewJ.M. Boulton, Anthony J. Koleske

The paper identifies variants in the TRIO PH2 domain that relieve autoinhibition of GEF2 activity, linking them to neurodevelopmental disorders.

2 citations

experimental assaychromatin & epigenetic regulation

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NeuroscienceeLifePeer-reviewedJun 9, 2025

Heterozygosity for neurodevelopmental disorder-associated TRIO variants yields distinct deficits in behavior, neuronal development, and synaptic transmission in mice.

Yevheniia Ishchenko, Amanda T. Jeng, Shufang Feng…·Anthony J. Koleske

This study examines how different heterozygous TRIO variants in mice affect behavior, brain development, and synaptic function, revealing distinct phenotypes linked to neurodevelopmental disorders.

4 citations

mousespatial transcriptomics

𝕏 PostBluesky