Author

Yevheniia Ishchenko

University of Eastern FinlandORCID 0000-0002-8631-9586Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Alice PébayiD· 1 shared Amanda T. Jeng· 1 shared Anastasia ShakirzyanovaiD· 1 shared Anthony J. KoleskeiD· 1 shared Charles A. GreeriD· 1 shared Cindy Manriquez-Rodriguez· 1 shared Damián HernándeziD· 1 shared Ellen E CorcoraniD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperNeuroscience

Alice PébayORCID

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2 papers

Recent·Most cited

Heterozygosity for neurodevelopmental disorder-associated TRIO variants yields distinct deficits in behavior, neuronal development, and synaptic transmission in mice.

Yevheniia Ishchenko, Amanda T. Jeng, Shufang Feng, Timothy Nottoli, Cindy Manriquez-Rodriguez, Khanh K Nguyen, Melissa G Carrizales, Matthew J Vitarelli, Ellen E Corcoran, Charles A. Greer, Samuel A. Myers, Anthony J. Koleske

This study examines how different heterozygous TRIO variants in mice affect behavior, brain development, and synaptic function, revealing distinct phenotypes linked to neurodevelopmental disorders.

eLife · Jun 9, 2025Peer-reviewedNeuroscience

Microglial amyloid beta clearance is driven by PIEZO1 channels

Henna Konttinen, Valeria Sitnikova, Yevheniia Ishchenko, Anastasia Shakirzyanova, Luca Giudice, Irene F. Ugidos, Mireia Gómez‐Budia, Nea Korvenlaita, Sohvi Ohtonen, Irina Belaya, Mohammad Feroze Fazaludeen, Nikita Mikhailov, Maria Gotkiewicz, Kirsi Ketola, Šárka Lehtonen, , Tarja Malm

This study shows that activating PIEZO1 channels in microglia improves amyloid beta clearance in AD models by enhancing survival, phagocytosis, and lysosomal activity.

bioRxiv · Mar 18, 2022 · PreprintNeuroscience