Anthony J. Koleske

This paper introduces pan-ExM-t, an all-optical method for visualizing specific proteins in the ultrastructural context of brain tissue, demonstrating its application on various markers in mouse brain sections and neuron cultures.

The paper identifies variants in the TRIO PH2 domain that relieve autoinhibition of GEF2 activity, linking them to neurodevelopmental disorders.

This study examines how different heterozygous TRIO variants in mice affect behavior, brain development, and synaptic function, revealing distinct phenotypes linked to neurodevelopmental disorders.

This study identifies Abl kinases as regulators of FGF signaling that prevent Peters anomaly by modulating RhoA and Rac1 activity through the Ptpn12-p130Cas pathway.

This study identifies latrophilin-2 as an upstream mechanosensor for fluid shear stress in endothelial cells, linking it to vascular development and disease.

This study shows Abl2:cortactin interactions maintain stable actin filaments in dendritic spines, which are critical for spine stability and structure.

This study identifies latrophilins as essential for endothelial cell mechanotransduction of fluid shear stress through both G protein-dependent and -independent pathways.