Haiqing Xiong

The paper introduces uCoTarget and uCoTargetX for high-throughput single-cell profiling of epigenetic proteins and transcriptomes, revealing epigenomic dynamics in hematopoietic stem/progenitor cell differentiation.

The paper uses single-cell epigenomic tracing to study endothelial cell plasticity across mouse organs from development to aging.

The paper introduces CoTECH, a method for joint detection of chromatin occupancy and transcriptome in single cells, revealing epigenetic mechanisms in cell fate decisions.

This paper develops an inducible CRISPRi system in mouse embryonic stem cells and generates a knockin mouse model for gene function studies.

CoBATCH enables high-throughput single-cell profiling of chromatin-binding proteins by combining combinatorial barcoding with targeted chromatin release, achieving high signal-to-noise and efficient epigenetic analysis.