Aibin He

NuMA promotes constitutive heterochromatin compaction by stabilizing linker histone H1 on chromatin

This study identifies NuMA's role in stabilizing linker histone H1 on chromatin to promote heterochromatin compaction and maintain epigenetic repression.

Capturing trophectoderm-like stem cells enables step-wisely remodeling of placental development

This paper captures mouse trophectoderm-like stem cells (TELSCs) that can generate all trophoblast lineages and form trophoblast organoids, providing insights into placental development.

Massively parallel single-cell profiling of transcriptome and multiple epigenetic proteins in cell fate regulation

The paper introduces uCoTarget and uCoTargetX for high-throughput single-cell profiling of epigenetic proteins and transcriptomes, revealing epigenomic dynamics in hematopoietic stem/progenitor cell differentiation.

Single-cell epigenomic tracing of lifelong endothelial cell plasticity across mouse organs

The paper uses single-cell epigenomic tracing to study endothelial cell plasticity across mouse organs from development to aging.

Single-cell joint detection of chromatin occupancy and transcriptome enables higher-dimensional epigenomic reconstructions

The paper introduces CoTECH, a method for joint detection of chromatin occupancy and transcriptome in single cells, revealing epigenetic mechanisms in cell fate decisions.

Generation and Validation of Versatile Inducible CRISPRi Embryonic Stem Cell and Mouse Models

This paper develops an inducible CRISPRi system in mouse embryonic stem cells and generates a knockin mouse model for gene function studies.

CoBATCH for high-throughput single-cell epigenomic profiling

CoBATCH enables high-throughput single-cell profiling of chromatin-binding proteins by combining combinatorial barcoding with targeted chromatin release, achieving high signal-to-noise and efficient epigenetic analysis.

The long noncoding RNA Hand2as orchestrates heart development through regulation of precise expression of HAND2

This study identifies Hand2as as a key lncRNA regulating HAND2 expression in heart development through single-cell RNA sequencing and knockout models, leading to congenital defects and perinatal lethality.