Shanshan Ai

This study identifies NuMA's role in stabilizing linker histone H1 on chromatin to promote heterochromatin compaction and maintain epigenetic repression.

CoBATCH enables high-throughput single-cell profiling of chromatin-binding proteins by combining combinatorial barcoding with targeted chromatin release, achieving high signal-to-noise and efficient epigenetic analysis.

This study identifies Hand2as as a key lncRNA regulating HAND2 expression in heart development through single-cell RNA sequencing and knockout models, leading to congenital defects and perinatal lethality.