Cell BiologybioRxivPreprint
Gut Microbiota Production of Phenylacetate Programs Vascular Niche Senescence and Drives Atherosclerosis
Khatereh Shabanian, Florentin Constancias, Benoît Pugin…·Seyed Soheil Saeedi Saravi
This study identifies phenylacetate (PAA), a gut microbiota metabolite, as a driver of vascular niche senescence and atherosclerosis in mice through IL-6-Notch1 signaling.