Author

Laurent Vallar

Luxembourg Institute of HealthORCID 0000-0002-4404-1010Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Approach:statistical model· 3 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Organism:mouse· 1

Frequent Co-Authors

Tony KaomaiD· 2 shared Alessia SciortinoiD· 1 shared Amer Ashrafi· 1 shared Chamseddine KifagiiD· 1 shared Charlotte Andrieu‐SoleriD· 1 shared Denis TempéiD· 1 shared Diana M. HendrickxiD· 1 shared Élise GuéretiD· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMolecular Biology

Tony KaomaORCID

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Author profile →

3 papers

Recent·Most cited

SUMOylation controls the rapid transcriptional reprogramming induced by anthracyclines in Acute Myeloid Leukemias

Mathias Boulanger, Chamseddine Kifagi, Marko Ristic, Ludovic Gabellier, Denis Tempé, Jón Otti Sigurðsson, Tony Kaoma, Charlotte Andrieu‐Soler, Thierry Forné, Éric Soler, Yosr Hicheri, Élise Guéret, Laurent Vallar, Jesper Velgaard Olsen, Guillaume Cartron, , Guillaume Bossis

This study shows that Daunorubicin induces transcriptional changes in AML cells through SUMO-dependent chromatin reconfiguration, affecting genes related to proliferation, death, and immunity.

bioRxiv · Apr 19, 2022 · PreprintMolecular Biology

Splice sites obey the power-law during splicing in leukemia cells

Vasily V. Grinev, Natalia Siomava, Laurent Vallar, Petr V. Nazarov

The paper identifies unisplice and multisplice splice sites in leukemia cells and shows their combinatorics follow a power-law, revealing hidden multisplice potential in unisplice sites.

bioRxiv · May 24, 2021 · PreprintBioinformatics

A new synuclein-transgenic mouse model for early Parkinson's reveals molecular features of preclinical disease

Diana M. Hendrickx, Pierre Garcia, Amer Ashrafi, Alessia Sciortino, Kristopher J. Schmit, Heike Kollmus, Nathalie Nicot, Tony Kaoma, Laurent Vallar, Manuel Buttini, Enrico Glaab

This study uses a synuclein-transgenic mouse model to identify molecular changes in early Parkinson's disease before neurodegeneration occurs.

Molecular Neurobiology · Sep 30, 2020Peer-reviewedNeuroscience