Alessandro Michelucci

The paper identifies impaired monocyte states and trajectories in glioblastoma patients through immune profiling, revealing systemic immune reprogramming and potential therapeutic targets.

This study develops humanized glioblastoma PDOX models to study tumor-immune interactions and test immunotherapies in a human context.

This study shows that a Miro1 mutation causes mitochondrial dysfunction and dopaminergic neuron loss in both cell models and mice, supporting its role in Parkinson's disease.

This study examines age-related changes in the nigro-striatal circuit across three mouse strains, revealing strain-specific differences in dopaminergic neuron integrity and highlighting the importance of considering strain and age in Parkinson's disease research.

The paper identifies Pttg1 as a key regulator of gene expression variation in mouse ventral midbrain across aging, showing its role in transcriptome shifts and cell-type-specific changes.

The paper investigates the role of alpha-synuclein spreading and inclusions in Parkinson disease using a mouse model, finding that neurodegeneration and microgliosis occur independently of inclusions.

The paper identifies Col4a6 as a genetic regulator of striatal dopamine levels and axonal branching in mice through QTL mapping and RNA-seq analysis.