Guillaume Bossis

Metabolic rewiring of cancer cells induces metastasis via ERK5 but triggers recognition by NK cells

This study shows that metabolic rewiring via fatty acid oxidation promotes cancer metastasis but also enhances NK cell recognition and killing of metastatic cells.

The SUMOylation inhibitor TAK-981 (Subasumstat) triggers IFN-I-dependent activation of Natural Killer cells against Acute Myeloid Leukemias.

This paper shows that TAK-981 activates NK cells against AML by inducing IFN-I secretion, enhancing their cytotoxicity and cytokine production.

TRIM28-dependent SUMOylation protects the adult ovary from the testicular pathway

This study identifies TRIM28's role in preventing female-to-male sex reversal in the adult mouse ovary by maintaining the ovarian pathway through SUMOylation.

SUMOylation controls the rapid transcriptional reprogramming induced by anthracyclines in Acute Myeloid Leukemias

This study shows that Daunorubicin induces transcriptional changes in AML cells through SUMO-dependent chromatin reconfiguration, affecting genes related to proliferation, death, and immunity.