Ning Wang

DNA replication in early mammalian embryos is patterned, predisposing lamina-associated regions to fragility

The paper shows that DNA replication patterns in early mammalian embryos are established early, with late replicating regions near the nuclear lamina showing fragility and predisposing long genes to genetic changes.

VarSCAT: A computational tool for sequence context annotations of genomic variants

VarSCAT annotates genomic variant sequence contexts, revealing that over 75% of human indels have breakpoint ambiguities and over 80% of STR region variants are indels.

Variant calling tool evaluation for variable size indel calling from next generation whole genome and targeted sequencing data

The paper evaluates variant calling tools for indel detection across different NGS datasets, showing tool and sequencing setting impacts on accuracy.