Giovanna Nascimento Scatolin

The paper develops a serum-free 6iL/E4 culture system that enables derivation and maintenance of embryonic stem cells (ESCs) across multiple mammalian species, revealing conserved mechanisms for ESC self-renewal.

This paper identifies METTL7A as a gene that enhances bovine IVF embryo development by reducing oxidative stress and mitochondrial damage.

This study establishes a method to derive and culture bovine extraembryonic endoderm cells (bXENs) using a chemical cocktail, revealing their role in maintaining stemness and supporting embryo development.

The paper shows that DNA replication patterns in early mammalian embryos are established early, with late replicating regions near the nuclear lamina showing fragility and predisposing long genes to genetic changes.

The paper maps the single-cell transcriptomes of bovine peri-implantation development to identify cell lineages and molecular mechanisms involved in early pregnancy success and failure.

The paper develops a method to generate bovine blastocyst-like structures (blastoids) from stem cells, which mimic blastocysts in morphology and transcriptomes.