Jeannine Gerhardt

APOBEC3A-Induced DNA Damage Drives Polymerase Theta Dependency and Synthetic Lethality in Cancer

This study identifies TMEJ as the main repair pathway for APOBEC3A-induced DSBs and shows Polθ inhibition causes synthetic lethality in cancer cells with APOBEC3A activity.

Dysregulation of the actin cytoskeleton and FMRP causes polar body protrusion defects in human fragile X premutation and aged oocytes

Polymerase Eta Recruits FANCD2 to Common Fragile Sites to Maintain Genome Stability

This study shows that polymerase Eta's PIP and UBZ domains are critical for managing replication stress at common fragile sites by recruiting FANCD2 and preventing DNA damage.

DNA replication in early mammalian embryos is patterned, predisposing lamina-associated regions to fragility

The paper shows that DNA replication patterns in early mammalian embryos are established early, with late replicating regions near the nuclear lamina showing fragility and predisposing long genes to genetic changes.

The Genetic Architecture of DNA Replication Timing in Human Pluripotent Stem Cells

This study identifies genetic regulators of DNA replication timing in human pluripotent stem cells, revealing a histone code and combinatorial regulatory mechanisms.

S-Phase induced RNAs control ORC1 engagement to H2A.Z and firing of early DNA replication origins.

The paper identifies S-phase RNAs that anchor ORC1 to H2A.Z, enabling DNA replication initiation and revealing an RNA-mediated mechanism for replication origin formation.