Author

Daniel S. Rizzuto

University of PennsylvaniaORCID 0000-0002-1293-9977Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 7 Assay:electronic health records· 6 Approach:statistical model· 5 Approach:experimental assay· 3 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Bradley Charles LegaiD· 8 shared Barbara C. JobstiD· 7 shared Gregory A. WorrelliD· 7 shared Michael J. KahanaiD· 7 shared Michael R. SperlingiD· 7 shared Robert E. GrossiD· 7 shared Sameer Anil ShethiD· 6 shared Sandhitsu R. DasiD· 6 shared

Activity by Year

2018-2025 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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8 shared papersNeuroscience

Bradley Charles LegaORCID

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Author profile →

8 papers

Recent·Most cited

A wireless, 60-channel, AI-enabled neurostimulation platform

Daniel S. Rizzuto, Haydn G. Herrema, Zhe Hu, Daniil Utin, Joshua Kahn, Chris Ho, Andrew B. Smiles, Robert E. Gross, Bradley Charles Lega, Sandhitsu R. Das, Michael J. Kahana

The paper introduces a wireless neurostimulation device that decodes brain states and delivers closed-loop stimulation in sheep, showing reliable classification of movement and modulation of spectral activity.

Brain stimulation · Dec 20, 2025Peer-reviewedNeuroscience

Functional and anatomical connectivity predict brain stimulation's mnemonic effects

Youssef Ezzyat, James E. Kragel, Ethan A. Solomon, Bradley Charles Lega, Joshua P. Aronson, Barbara C. Jobst, Robert E. Gross, Michael R. Sperling, Gregory A. Worrell, Sameer Anil Sheth, Paul A. Wanda, Daniel S. Rizzuto, Michael J. Kahana

The paper tests if targeting brain stimulation based on anatomical and functional network properties improves memory in patients.

Cerebral Cortex · Nov 2, 2023Peer-reviewedNeuroscience

The effects of direct brain stimulation in humans depend on frequency, amplitude, and white-matter proximity.

Uma R. Mohan, Andrew J. Watrous, Jonathan F. Miller, Bradley Charles Lega, Michael R. Sperling, Gregory A. Worrell, Robert E. Gross, Kareem A. Zaghloul, Barbara C. Jobst, Kathryn A. Davis, Sameer Anil Sheth, Joel M. Stein, Sandhitsu R. Das, Richard Gorniak, Paul A. Wanda, , Joshua Jacobs

This study examines how direct brain stimulation affects neuronal activity in humans, finding that frequency, amplitude, and electrode location influence whether stimulation inhibits or excites activity.

Brain stimulation · May 21, 2020Peer-reviewedNeuroscience

Risk of Seizures Induced by Intracranial Research Stimulation: Analysis of 770 Stimulation Sessions

Hannah E. Goldstein, Elliot H. Smith, Robert E. Gross, Barbara C. Jobst, Bradley Charles Lega, Michael R. Sperling, Gregory A. Worrell, Kareem A. Zaghloul, Paul A. Wanda, Michael J. Kahana, Daniel S. Rizzuto, Catherine A. Schevon, Guy M. McKhann, Sameer Anil Sheth

The paper analyzes 770 intracranial stimulation sessions to assess the risk of stimulation-induced seizures, finding 3-6% of sessions likely or possibly caused seizures with no adverse outcomes.

Journal of Neural Engineering · Sep 11, 2019Peer-reviewedNeuroscience

Functional wiring of the human medial temporal lobe

Ethan A. Solomon, Joel M. Stein, Sandhitsu R. Das, Richard Gorniak, Michael R. Sperling, Gregory A. Worrell, Cory S. Inman, Bradley Charles Lega, Barbara C. Jobst, Daniel S. Rizzuto, Michael J. Kahana

The paper investigates functional connectivity in the human medial temporal lobe during memory tasks, identifying theta-band synchronization and reorganization patterns associated with encoding and retrieval.

bioRxiv · Jul 3, 2018 · PreprintNeuroscience

MTL functional connectivity predicts stimulation-induced theta power

Ethan A. Solomon, Robert E. Gross, Bradley Charles Lega, Michael R. Sperling, Gregory A. Worrell, Sameer Anil Sheth, Kareem A. Zaghloul, Barbara C. Jobst, Joel M. Stein, Sandhitsu R. Das, Richard Gorniak, Cory S. Inman, Sarah E. Seger, James E. Kragel, Daniel S. Rizzuto, Michael J. Kahana

The paper shows that functional connectivity predicts changes in theta power from electrical stimulation, but only when stimulation occurs in or near white matter.

bioRxiv · May 15, 2018 · PreprintNeuroscience

Predictive control of electrophysiological network architecture using direct, single-node neurostimulation in humans

Ankit N. Khambhati, Ari E. Kahn, Julia G. Costantini, Youssef Ezzyat, Ethan A. Solomon, Robert E. Gross, Barbara C. Jobst, Sameer Anil Sheth, Kareem A. Zaghloul, Gregory A. Worrell, Sarah E. Seger, Bradley Charles Lega, Shennan A. Weiss, Michael R. Sperling, Richard Gorniak, , Danielle S. Bassett

This study uses network control theory to predictably reconfigure brain network interactions through targeted neurostimulation in humans.

bioRxiv · Mar 31, 2018 · PreprintNeuroscience

Electrophysiological signatures of spatial boundaries in the human subiculum

Sang Ah Lee, Jonathan F. Miller, Andrew J. Watrous, Michael R. Sperling, Ashwini Dayal Sharan, Gregory A. Worrell, Brent M Berry, Barbara C. Jobst, Kathryn A. Davis, Robert E. Gross, Bradley Charles Lega, Sameer Anil Sheth, Sandhitsu R. Das, Joel M. Stein, Richard Gorniak, , Joshua Jacobs

The paper identifies electrophysiological signatures of spatial boundaries in the human subiculum using intracranial recordings during a virtual navigation task.

Journal of Neuroscience · Feb 21, 2018Peer-reviewedNeuroscience