Bradley Charles Lega

This study identifies GAA accumulation in gliomas as a driver of neuronal activity and tumor growth, linking cancer metabolism to neuroscience through GABAA receptor activation.

The paper identifies time cells and their role in temporal context recovery during episodic memory retrieval using human neurosurgical recordings.

The paper links hippocampal oscillatory activity during memory encoding to distinct molecular programs in anterior and posterior hippocampus using single-nucleus RNA sequencing and spatial transcriptomics.

The paper introduces a wireless neurostimulation device that decodes brain states and delivers closed-loop stimulation in sheep, showing reliable classification of movement and modulation of spectral activity.

The paper investigates neural components specific to episodic memory by analyzing cross-task decoding in patients performing free recall and arithmetic tasks.

The paper shows that stimulation increases firing rates in pyramidal cells and strengthens cell assemblies in the human temporal cortex, linked to gene networks involving excitatory neurons and non-neurons.

This study shows that cholinergic blockade disrupts hippocampal theta oscillations during memory encoding but not retrieval, suggesting theta reflects an encoding state rather than being required for retrieval.

This study shows that low-frequency hippocampal oscillations during navigation and mental simulation share overlapping patterns, suggesting a broader memory-related role than a specific navigation function.

The paper tests if targeting brain stimulation based on anatomical and functional network properties improves memory in patients.

This study shows that spontaneous reactivation during encoding predicts memory recall, supporting rapid consolidation processes.

This study examines how episodic boundaries influence neural features of representational drift in humans during a free recall task, showing regional differences in how drift is reset or used for memory association.

The paper identifies neuronal assemblies in the human MTL using microelectrode data and shows they are linked to memory performance and exhibit flexible adjustment over time.

The paper identifies cortical networks that reinstated semantic content and temporal context during episodic recall, showing how specialized systems organize memory retrieval.

This study examines the relationship between fMRI BOLD signals and gamma-band activity in the hippocampus and neocortex, finding region-specific correlations.

The paper identifies boundary neurons in the human hippocampus that fire at the start and end of episodes during a free recall task, using a generalized linear model and spike-field coherence analysis.

The paper identifies oscillatory biomarkers of memory variability in TBI patients and controls, showing similar patterns of spectral power and theta connectivity during successful memory formation.

This study identifies 2-5 Hz hippocampal theta oscillations as selectively associated with successful associative memory encoding and retrieval in humans using intracranial EEG.

The paper identifies time cells in the human hippocampus and entorhinal cortex that predict episodic memory temporal organization and exhibit phase precession.

This study examines how direct brain stimulation affects neuronal activity in humans, finding that frequency, amplitude, and electrode location influence whether stimulation inhibits or excites activity.

The paper investigates human hippocampal theta oscillations, finding distinct high (8-Hz) and low (3-Hz) frequencies associated with spatial navigation and non-spatial processes respectively.

This paper links brain oscillations to gene expression in human patients, identifying gene modules associated with memory encoding and neuropsychiatric disorders.

The paper shows that hippocampal theta oscillations encode semantic and temporal distances between words during memory retrieval.

The paper analyzes 770 intracranial stimulation sessions to assess the risk of stimulation-induced seizures, finding 3-6% of sessions likely or possibly caused seizures with no adverse outcomes.

The paper examines gamma oscillations during episodic memory tasks and finds reversed information flow between the hippocampus and prefrontal cortex during encoding and retrieval.

This study uses deep brain stimulation to show that stimulating the posterior cingulate cortex impairs episodic memory encoding and modulates hippocampal activity.

The paper uses intracranial EEG data to identify brain networks involved in mental arithmetic, revealing contributions from parietal and extra-parietal regions and hemispheric differences.

The paper identifies trace cells in the human entorhinal cortex that remap their spatial fields to represent memory cues during cued recall.

The paper investigates functional connectivity in the human medial temporal lobe during memory tasks, identifying theta-band synchronization and reorganization patterns associated with encoding and retrieval.

The paper shows that functional connectivity predicts changes in theta power from electrical stimulation, but only when stimulation occurs in or near white matter.