Kareem A. Zaghloul

Inflammatory signaling differentially changes chromatin accessibility and gene expression of the PD- associated kinase LRRK2 between human and mice

The paper shows that inflammatory signaling affects LRRK2 regulation differently in human and mouse models, highlighting species-specific regulatory mechanisms.

Neural components underlying successful free recall are specific to episodic memory

The paper investigates neural components specific to episodic memory by analyzing cross-task decoding in patients performing free recall and arithmetic tasks.

A novel, evolutionarily conserved inhibitory circuit selectively regulates dentate gyrus mossy cell function.

The paper identifies a novel inhibitory interneuron subtype in the dentate gyrus that selectively regulates mossy cell function and shows this pattern is evolutionarily conserved across species.

Reactivation of reward representations associated with the reinforcement of behavior

The paper investigates how reward-related neural representations are reactivated during learning to reinforce behavior, finding that reactivation occurs when reward contingencies are consistent across tasks.

Divergent opioid-mediated suppression of inhibition between hippocampus and neocortex across species and development

The paper shows that opioids suppress inhibition in hippocampal PV-INs but not neocortex across species and development, highlighting conserved and divergent roles in neural circuits.

The Entorhinal-DG/CA3 Pathway in the Medial Temporal Lobe Retains Visual Working Memory of a Simple Surface Feature

This study investigates whether the entorhinal-DG/CA3 pathway supports visual working memory of a simple surface feature using an orientation WM task and fMRI.

Discrete ripples reflect a spectrum of synchronous spiking activity in human association cortex

This study shows that cortical ripples in human temporal cortex are linked to neuronal spiking synchrony and contribute to broadband high frequency activity.

Neural Fragility as an EEG Marker of the Seizure Onset Zone

The paper introduces and validates neural fragility as an EEG biomarker for identifying the seizure onset zone, showing higher prediction accuracy than clinician judgment.

Distinct cortical systems reinstate the content and context of episodic memories

The paper identifies cortical networks that reinstated semantic content and temporal context during episodic recall, showing how specialized systems organize memory retrieval.

Viral manipulation of functionally distinct neurons from mice to humans

The paper identifies enhancers for targeting specific neuronal subtypes across species and demonstrates their utility in circuit manipulation.

Activity-dependent tuning of intrinsic excitability in mouse and human neurogliaform cells

The paper shows that neurogliaform cells in mouse and human exhibit similar activity-dependent changes in intrinsic excitability, suggesting conserved circuit mechanisms across species.

The effects of direct brain stimulation in humans depend on frequency, amplitude, and white-matter proximity.

This study examines how direct brain stimulation affects neuronal activity in humans, finding that frequency, amplitude, and electrode location influence whether stimulation inhibits or excites activity.

Low frequency traveling waves in the human cortex coordinate neural activity across spatial scales

The paper examines low frequency traveling waves in the human cortex and finds they coordinate neural activity across spatial scales and with single unit spiking.

Identifying site- and stimulation-specific TMS-evoked EEG potentials using a quantitative cosine similarity metric

This study identifies TMS-evoked EEG potentials (TEPs) that are site- and stimulation-specific by analyzing cosine similarity across different stimulation sites and active vs. sham TMS.

Risk of Seizures Induced by Intracranial Research Stimulation: Analysis of 770 Stimulation Sessions

The paper analyzes 770 intracranial stimulation sessions to assess the risk of stimulation-induced seizures, finding 3-6% of sessions likely or possibly caused seizures with no adverse outcomes.

Intracranial EEG reveals bihemispheric parietal and extra parietal brain networks supporting mental arithmetic

The paper uses intracranial EEG data to identify brain networks involved in mental arithmetic, revealing contributions from parietal and extra-parietal regions and hemispheric differences.

MTL functional connectivity predicts stimulation-induced theta power

The paper shows that functional connectivity predicts changes in theta power from electrical stimulation, but only when stimulation occurs in or near white matter.

Predictive control of electrophysiological network architecture using direct, single-node neurostimulation in humans

This study uses network control theory to predictably reconfigure brain network interactions through targeted neurostimulation in humans.

Using Network Analysis to Localize the Epileptogenic Zone from Invasive EEG Recordings in Intractable Focal Epilepsy

The paper develops a network analysis algorithm to localize the epileptogenic zone using invasive EEG recordings, showing better agreement with clinical outcomes in successful surgeries.

Signal complexity of human intracranial EEG tracks successful associative memory formation across individuals

The paper identifies neural signal complexity metrics in intracranial EEG that correlate with successful associative memory formation across individuals.

Dual origins of measured phase-amplitude coupling reveal distinct neural mechanisms underlying episodic memory in the human cortex

The paper examines phase-amplitude coupling in the human cortex during memory tasks and finds that decreases in PAC in specific brain regions are linked to two distinct neural mechanisms.