NeuroscienceScience AdvancesPeer-reviewed
Ligands binding to the cellular prion protein induce its protective proteolytic release with therapeutic potential in neurodegenerative proteinopathies
Luise Linsenmeier, Behnam Mohammadi, Mohsin Shafiq…·Markus Glatzel
The paper shows that ligands binding to PrPC induce its proteolytic release, which has neuroprotective effects, and identifies mechanisms and exceptions in this process.
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