Behnam Mohammadi

STED-FCS in subdiffraction limit volumes reveals altered diffusion in live cell applications

This study demonstrates the application of STED-FCS in live cell assays to analyze molecular diffusion, showing its utility in studying autophagy, glycoprotein dynamics, and lipid mobility in disease contexts.

Efficient enzyme-free isolation of brain-derived extracellular vesicles

This paper demonstrates that non-enzymatic methods can isolate brain-derived extracellular vesicles without compromising protein integrity, achieving high yield and purity.

Cleavage site-directed antibodies reveal the prion protein in humans is shed by ADAM10 at Y226 and associates with misfolded protein deposits in neurodegenerative diseases

This study identifies ADAM10-mediated shedding of human PrP at Y226 and shows sPrP associates with misfolded protein aggregates in neurodegenerative diseases.

Ligands binding to the cellular prion protein induce its protective proteolytic release with therapeutic potential in neurodegenerative proteinopathies

The paper shows that ligands binding to PrPC induce its proteolytic release, which has neuroprotective effects, and identifies mechanisms and exceptions in this process.

BRAIN-DERIVED EXTRACELLULAR VESICLES ARE HIGHLY ENRICHED IN THE PRION PROTEIN AND ITS C1 FRAGMENT: RELEVANCE FOR CELLULAR UPTAKE AND IMPLICATIONS IN STROKE

This study characterizes brain-derived extracellular vesicles (sEVs) in mice under normal and post-stroke conditions, showing increased PrP and PrP-C1 content and altered cellular uptake.