Antoine Triller

The paper investigates competition between glycine and GABA receptors for gephyrin at inhibitory synapses using single-molecule techniques and molecular tweezers, revealing thermodynamic properties and implications for synaptic plasticity.

This study shows that AUTS2 gene dosage affects synaptic AMPA receptors through the AUTS2-TTC3-AKT-mTORC1 pathway, leading to behavioral and cognitive impairments in mice.

This study shows microglial TNFα regulates brain phosphorylation during sleep, affecting sleep need and duration through synaptic proteins.

The paper shows microglial TNFα regulates GABAAR plasticity, sleep slow waves, and memory consolidation through purinergic signaling.

The paper quantifies the molecular arrangement of glycine receptors at spinal cord synapses, showing consistent packing densities despite morphological differences.

The paper shows that ligands binding to PrPC induce its proteolytic release, which has neuroprotective effects, and identifies mechanisms and exceptions in this process.

The paper shows that presynaptic NMDARs in granule cells are essential for bidirectional synaptic plasticity and motor learning in adult rodents.

The paper uses super-resolution imaging to show that GlyRs and GABAARs form distinct sub-synaptic domains at mixed inhibitory synapses, with differential regulation of GABAARs under increased network activity.

This study shows GlyRs and gephyrin dynamically stabilise each other at inhibitory synapses through receptor-scaffold interactions, with GlyR crosslinking reducing gephyrin exchange but not total synaptic levels.

This study identifies SUSD4 as a regulator of GLUA2 degradation and synaptic plasticity, showing its role in motor learning and implications for neurodevelopmental diseases.

The paper develops a 3D-CLEM approach to study spine ultrastructure in mouse somatosensory cortex and models its impact on synaptic inhibition.