Ligands binding to the cellular prion protein induce its protective proteolytic release with therapeutic potential in neurodegenerative proteinopathies
Luise Linsenmeier, Behnam Mohammadi, Mohsin Shafiq, Karl Frontzek, Julia Bär, Amulya Nidhi Shrivastava, Markus Daμμe, Feizhi Song, Alexander Schwarz, Stefano Da Vela, Tania Massignan, Sebastian Jung, Angela da Silva Correia, Matthias Schmitz, Berta Puig, , Markus Glatzel
The paper shows that ligands binding to PrPC induce its proteolytic release, which has neuroprotective effects, and identifies mechanisms and exceptions in this process.
Science Advances · Nov 24, 2021Peer-reviewedNeuroscience