Author

Luise Linsenmeier

University Medical Center Hamburg-EppendorfORCID 0000-0002-4680-7622Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:protein structure· 2 Research Focus:protein structure prediction· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Behnam MohammadiiD· 2 shared Berta PuigiD· 2 shared Feizhi SongiD· 2 shared Hermann C. AltmeppeniD· 2 shared Inga ZerriD· 2 shared Jörg TatzeltiD· 2 shared Markus DaμμeiD· 2 shared Markus GlatzeliD· 2 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Behnam MohammadiORCID

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2 papers

Recent·Most cited

Cleavage site-directed antibodies reveal the prion protein in humans is shed by ADAM10 at Y226 and associates with misfolded protein deposits in neurodegenerative diseases

Feizhi Song, Valerija Kovač, Behnam Mohammadi, Jessica Lisa Littau, Franka Scharfenberg, Andreu Matamoros‐Angles, Ilaria Vanni, Mohsin Shafiq, Leonor Orge, Giovanna Galliciotti, Salma Djakkani, Luise Linsenmeier, Maja Černilec, Katrina Pretnar Hartman, Sebastian Jung, , Hermann C. Altmeppen

This study identifies ADAM10-mediated shedding of human PrP at Y226 and shows sPrP associates with misfolded protein aggregates in neurodegenerative diseases.

Acta Neuropathologica · Jul 9, 2024Peer-reviewedNeuroscience

Ligands binding to the cellular prion protein induce its protective proteolytic release with therapeutic potential in neurodegenerative proteinopathies

Luise Linsenmeier, Behnam Mohammadi, Mohsin Shafiq, Karl Frontzek, Julia Bär, Amulya Nidhi Shrivastava, Markus Daμμe, Feizhi Song, Alexander Schwarz, Stefano Da Vela, Tania Massignan, Sebastian Jung, Angela da Silva Correia, Matthias Schmitz, Berta Puig, , Markus Glatzel

The paper shows that ligands binding to PrPC induce its proteolytic release, which has neuroprotective effects, and identifies mechanisms and exceptions in this process.

Science Advances · Nov 24, 2021Peer-reviewedNeuroscience