Charles J. Heckman

This study examines how menstrual cycle-related sex hormone fluctuations affect motor unit discharge properties, finding small but detectable effects on discharge rates and patterns.

This study shows that Sall3 is essential for forming GABApre synapses on Ia afferents, and its loss disrupts motor behavior by impairing presynaptic inhibition.

The paper examines muscle-specific changes in motor unit firing characteristics in elbow flexors and extensors after cervical spinal cord injury, finding altered rate coding in biceps brachii but not triceps brachii.

This study shows that riluzole increases motoneuron excitability in ALS mice due to hyperactive homeostasis, which counteracts the drug's intended effects.

This study examines the role of the 5-HT2C receptor in motor behavior of mice with and without spinal cord injury, finding sex- and injury-dependent changes in receptor expression and function.

This study develops reverse engineering techniques to identify synaptic inputs from neuron firing patterns using supercomputers, showing they can accurately reconstruct input combinations with 75-90% variance accounted for.

This study examines how voluntary co-contraction of ankle muscles affects motor unit discharge and reduces persistent inward currents (PICs) in motoneurons.

This study identifies and characterizes a new postural motor response to spinal cord stimulation called LEAP, which has potential for clinical applications in motor disorders.

This study shows that GABA facilitates sensory transmission in monkeys, increasing spinal and cortical neural responses to sensory inputs.

The paper quantifies sex differences in motor unit discharge rates and persistent inward current estimates in human lower limb muscles, finding higher {Delta}F in females.

The paper introduces a Bayesian MCMC method with adaptive parallel tempering to estimate parameters and quantify uncertainty in Hodgkin-Huxley neuron models using voltage trace data.

The paper shows that spinal motoneurons in ALS mice maintain excitability through homeostasis, but this process pushes some cells beyond normal conductance ranges, potentially contributing to degeneration.

This study evaluates how different computational parameters affect the {Delta}F technique for estimating motoneuron excitability using paired motor unit analysis.