ImmunologybioRxivPreprint
Potentiating CAR-T bystander killing by enhanced Fas/FasL signaling mitigates antigen escape in heterogeneous tumors
Matthew Junda Lin, Joanna K Chorazeczewski, Gvantsa Pantsulaia…·Joshua Brody
This study shows that enhancing Fas/FasL signaling improves CAR-T cell bystander killing against antigen-negative tumor cells, reducing antigen escape and improving therapeutic outcomes.