Author

Joshua Brody

Icahn School of Medicine at Mount SinaiORCID 0000-0002-0850-6730Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Brian D. BrowniD· 3 shared Miriam MéradiD· 2 shared Moah SohniD· 2 shared Abishek Balachandra VaidyaiD· 1 shared Abraham J. P. TeunisseniD· 1 shared Adam R. MarksiD· 1 shared Alan Cooper· 1 shared Alexander TepperiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersImmunology

Brian D. BrownORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Dendritic cells type 1 control the formation, maintenance, and function of tertiary lymphoidstructures in cancer

Raphaël Mattiuz, Jesse Boumelha, Emmanouil Aerakis, Jessica Le Bérichel, Pauline Hamon, László Halász, Abishek Balachandra Vaidya, Brian Y. Soong, Emir Radkevich, Hye Mi Kim, Matthew D. Park, Romain Donné, Leanna Troncoso, Rachel A. Kaplan, Clotilde Hennequin, , Miriam Mérad

This study identifies the role of mature dendritic cells type 1 in forming, maintaining, and functioning tertiary lymphoid structures in cancer.

Science · Jul 16, 2026Peer-reviewedImmunology

Transcriptome sequencing of Hodgkin lymphoma Hodgkin and Reed-Sternberg cells reveals escape from NK cell recognition and an unfolded protein response

Mikhail Roshal, Isabella Y. Kong, Wikum Dinalankara, Jonathan B. Reichel, Matt R. Teater, Bhavneet Binder, Sakellarios Zairis, Joshua Brody, Sunita I. Park, Alexandra E. Kovach, Nitya Gulati, Matthew James Oberley, Megan S. Lim, Matthew John Barth, Olivier Elemento, , Ethel Cesarman

This study identifies unique transcriptional features of Hodgkin lymphoma HRS cells, including immune evasion mechanisms and an unfolded protein response, distinguishing them from other B-cell lymphomas.

Blood Cancer Journal · Apr 22, 2026Peer-reviewedCancer Biology

Potentiating CAR-T bystander killing by enhanced Fas/FasL signaling mitigates antigen escape in heterogeneous tumors

Matthew Junda Lin, Joanna K Chorazeczewski, Gvantsa Pantsulaia, Alan Cooper, Moah Sohn, Sidorela Reci, Jaime Mateus-Tique, Nicole H. Hirsh, Xin-Ping Xie, Ivan Odak, Rudra Prasad Dutta, Daniel Charytonowicz, Ranjan Upadhyay, Brian D. Brown, Miriam Mérad, , Joshua Brody

This study shows that enhancing Fas/FasL signaling improves CAR-T cell bystander killing against antigen-negative tumor cells, reducing antigen escape and improving therapeutic outcomes.

bioRxiv · Sep 22, 2025 · PreprintImmunology

Bispecific antibody targeting of lipid nanoparticles

Angelo Amabile, Matthew Phelan, Zhe Yu, Pedro Silva, Adam R. Marks, Judit Morlà‐Folch, Moah Sohn, Gürkan Mollaoglu, Chiara Falcomatà, Abraham J. P. Teunissen, Joshua Brody, Yizhou Dong, Brian D. Brown

This paper develops a method to conjugate bispecific antibodies to lipid nanoparticles for targeted mRNA delivery, showing improved efficiency and specificity in transfecting specific cell types.

bioRxiv · Dec 20, 2024 · PreprintBioengineering